DSIP
Limited human dataNonapeptide studied for sleep onset and regulation.
The catch: The human literature is small, dated and largely unreplicated, and it is not FDA-approved.
Peptides for Sleep
Last reviewed 2026-08-25
The honest answer first
DSIP is essentially the only peptide marketed specifically for sleep, and its evidence base is thin, dated and largely unreplicated. It is not FDA-approved, and we have found no approved sleep indication for it in the United States. For most people with a sleep problem, cognitive behavioural therapy for insomnia has far better evidence than anything on this page.
Delta sleep-inducing peptide was first described in 1977, isolated from the cerebral venous blood of rabbits during induced sleep — an origin that captures both why it is interesting and how old the underlying work is.
Most of the human research dates from the 1980s and 1990s and has not been meaningfully replicated since. Growth hormone secretagogues are also sometimes reported to improve sleep quality, which is a secondary effect rather than their purpose.
What gets used for sleep, and what backs it
Every entry carries the level of human evidence for this use — not the compound’s approval status for something else.
| Peptide | Evidence for this goal | FDA status | Typical cost/mo |
|---|---|---|---|
| DSIP | Limited human data | Research | Not published |
What has the strongest support
Nothing here has good modern evidence. Cognitive behavioural therapy for insomnia has substantially better support than any peptide sold for sleep.
Medical Disclaimer: This content is for informational purposes only and should not be considered medical advice. Always consult with a qualified healthcare provider before beginning any peptide therapy treatment.
Frequently Asked Questions
The evidence is limited, mostly from small studies in the 1980s and 1990s, and has not been meaningfully replicated. It is not FDA-approved.
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