Sermorelin Dosage Chart
Pre-bed protocol, 5-day-per-week schedule, and reconstitution math for the 5 mg vial — the entry-level GHRH analog.
Educational tool — not medical advice. This calculator provides estimates based on population averages and published trial data. Outputs are not clinical recommendations and do not replace evaluation by a qualified prescriber. Do not start, stop, or change a peptide therapy based on the result of this tool.
Sermorelin is a GHRH analog (residues 1–29 of native GHRH) that was previously FDA-approved as Geref for pediatric growth hormone deficiency, but commercial production was discontinued in 2008. It remains widely available through 503A/503B compounding pharmacies for off-label adult use. Compared to CJC-1295, it has a shorter half-life and produces a more transient GH pulse — many clinicians consider it the entry-level GHRH option.
Sermorelin at a Glance
| Typical dose | 200–500 mcg subQ pre-bed |
|---|---|
| Frequency | 5 days per week (Mon–Fri pattern is common) |
| Best timing | Pre-bed, 90+ min after last meal |
| Cycle length | 3–6 months typical; long-term continuous use is common in anti-aging clinics |
| FDA status | Geref FDA approval for pediatric GHD discontinued 2008. Adult use is off-label compounded. |
| Common vial size | 5 mg or 15 mg lyophilized powder |
Sermorelin Reconstitution Chart
How vial size, bacteriostatic water volume, and insulin-syringe units convert for Sermorelin. Use this to translate a prescribed mcg or mg dose into a syringe measurement.
| Vial size | Bac water | Concentration | Dose → insulin-syringe units (U-100) |
|---|---|---|---|
| 5 mg | 2 mL | 2.5 mg/mL (250 mcg per 0.1 mL) |
|
| 15 mg | 5 mL | 3 mg/mL (300 mcg per 0.1 mL) |
|
Sermorelin Dosing by Use Case
Commonly cited protocols vary by what Sermorelin is being used for. The table below summarizes typical ranges reported in clinical practice and published literature.
| Use case | Typical dose | Frequency | Cycle length | Notes |
|---|---|---|---|---|
| Adult anti-aging / GH support | 200–500 mcg | Pre-bed, 5 days/week | 3–6 months continuous, then assess | Default off-label adult protocol. Pre-bed timing aligns with overnight GH pulse. |
| Sleep support | 200 mcg | Pre-bed, 5 days/week | 8–12 weeks | Lower-dose protocol focused on sleep quality rather than body composition. |
Stacking Sermorelin
Sermorelin is occasionally paired with ipamorelin to combine GHRH and ghrelin-receptor activation, but this is less common than the CJC-1295 + ipamorelin pairing because sermorelin's shorter half-life produces less synergy. Choose sermorelin OR CJC-1295 — not both.
Sermorelin has the longest clinical track record among compounded GH-releasing peptides and a generally clean safety profile.
- •Common side effects: injection-site reactions, transient flushing or headache, vivid dreams.
- •Endogenous GH release pathway — has a built-in negative-feedback ceiling that limits supraphysiologic GH spikes.
- •Theoretical concern with chronic GH/IGF-1 elevation: facilitation of cancer growth in patients with malignancy.
- •Long-term use beyond 12 months is common in anti-aging clinics but is not formally validated for safety.
- •Active or recent malignancy
- •Untreated hypothyroidism (treat first)
- •Pregnancy or breastfeeding
Sermorelin Dosing FAQ
Sermorelin has a shorter half-life and produces a more transient GH pulse — closer to natural GHRH biology. CJC-1295 (especially no-DAC) is more often paired with ipamorelin in modern protocols. If you want the entry-level GHRH and tighter physiologic mimicry, sermorelin. If you want stronger pulse synergy with ipamorelin, no-DAC CJC-1295.
Anti-aging clinics commonly run sermorelin 3–6 months continuously, sometimes longer. Long-term safety beyond 12 months at adult doses is not formally validated. Most clinicians take 4-week breaks every 6 months.
The largest natural GH pulse of the day occurs during the first phase of deep sleep. Dosing pre-bed (90+ minutes after the last meal, on an empty stomach) layers the peptide-driven pulse onto this natural release window for an additive effect.
Sources
Related Dosage Charts
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Mechanism, clinical evidence, side effects, costs, and provider listings for Sermorelin therapy.
See Sermorelin guideMedical Disclaimer: This content is for informational purposes only and should not be considered medical advice. Always consult with a qualified healthcare provider before beginning any peptide therapy treatment.