Sermorelin Dosage Chart
Adult clinic-convention pre-bed protocol, 5-day-per-week schedule, and reconstitution math for the 5 mg vial.
Fact-checking at PeptideProbe is editorial, not clinical. Our editors check claims, dosing figures, and trial results against primary sources; they are not licensed clinicians and do not provide medical review. Nothing here is medical advice — talk to a qualified healthcare provider before starting any therapy.
Educational tool — not medical advice. This calculator provides estimates based on population averages and published trial data. Outputs are not clinical recommendations and do not replace evaluation by a qualified prescriber. Do not start, stop, or change a peptide therapy based on the result of this tool.
Sermorelin is a GHRH analog (residues 1–29 of native GHRH) with clinical-study history in pediatric growth hormone deficiency. It remains available through 503A/503B compounding pharmacies for off-label adult use, but adult wellness dosing is a different population and rationale than the cited pediatric study. Compared to CJC-1295, it has a shorter half-life and produces a more transient GH pulse.
Sermorelin at a Glance
| Typical dose | 200–500 mcg subQ pre-bed (adult clinic convention) |
|---|---|
| Frequency | 5 days per week (clinic convention; Mon–Fri pattern is common) |
| Best timing | Pre-bed, 90+ min after last meal |
| Cycle length | 3–6 months commonly used in clinics; not derived from the cited pediatric study |
| FDA status | No current FDA-approved sermorelin product. Adult use is off-label compounded. |
| Common vial size | 5 mg or 15 mg lyophilized powder |
Sermorelin Reconstitution Chart
How vial size, bacteriostatic water volume, and insulin-syringe units convert for Sermorelin. Use this to translate a prescribed mcg or mg dose into a syringe measurement.
| Vial size | Bac water | Concentration | Dose → insulin-syringe units (U-100) |
|---|---|---|---|
| 5 mg | 2 mL | 2.5 mg/mL (250 mcg per 0.1 mL) |
|
| 15 mg | 5 mL | 3 mg/mL (300 mcg per 0.1 mL) |
|
Sermorelin Dosing by Use Case
Commonly cited protocols vary by what Sermorelin is being used for. The table below summarizes typical ranges reported in clinical practice and published literature.
| Use case | Typical dose | Frequency | Cycle length | Notes |
|---|---|---|---|---|
| Adult wellness / GH support (clinic convention) | 200–500 mcg | Pre-bed, 5 days/week | 3–6 months continuous, then assess | Default off-label adult clinic protocol; not derived from the pediatric GHD study. |
| Sleep-support protocol (clinic convention) | 200 mcg | Pre-bed, 5 days/week | 8–12 weeks | Lower-dose clinic protocol focused on patient-reported sleep quality; not a studied indication in the cited source. |
Stacking Sermorelin
In clinic/vendor protocols, sermorelin is sometimes paired with ipamorelin to combine GHRH and ghrelin-receptor activation, but no cited source here tests that combination. If comparing sermorelin with CJC-1295, treat that as a protocol choice in practice rather than a head-to-head outcome supported by these sources.
Where these numbers come from
The cited clinical study tested once-daily bedtime subcutaneous GHRH(1-29) at 30 mcg/kg/day in prepubertal children with growth-hormone deficiency for one year. It does not establish fixed adult 200-500 mcg anti-aging or sleep dosing; that is a different population, goal, and dosing rationale. The adult protocol shown here is clinic convention for compounded sermorelin, not an FDA-label protocol or a dose derived from the cited pediatric study.
Sermorelin has pediatric clinical-study history as GHRH(1-29), but adult wellness protocols have a thinner evidence base.
- •Common side effects: injection-site reactions, transient flushing or headache, vivid dreams.
- •Endogenous GH release pathway — has a built-in negative-feedback ceiling that limits supraphysiologic GH spikes.
- •Theoretical concern with chronic GH/IGF-1 elevation: facilitation of cancer growth in patients with malignancy.
- •Long-term adult use at wellness doses is not formally validated for safety.
- •Active or recent malignancy
- •Untreated hypothyroidism (treat first)
- •Pregnancy or breastfeeding
Sermorelin Dosing FAQ
The cited pediatric study does not answer this adult comparison. Sermorelin is shorter-acting than long-acting CJC-1295 with DAC, while no-DAC CJC-1295/Mod GRF appears in many clinic CJC/Ipa protocols. Those adult protocol choices are practitioner convention, not head-to-head clinical evidence.
There is no FDA-labeled adult wellness duration. This chart's 3–6 month cycle is clinic convention, and long-term safety at adult wellness doses is not formally validated.
The cited pediatric study dosed GHRH(1-29) at bedtime, and adult clinic protocols often carry that timing forward to align with overnight GH physiology. That does not make the adult pre-bed protocol a validated anti-aging or sleep regimen.
Sources
Related Dosage Charts
Where to get Sermorelin with a prescription
Sermorelin requires a prescription and medical supervision. Each service below states that a licensed provider reviews your intake and prescribes through a US compounding pharmacy where appropriate. Those are the companies’ own descriptions of how they operate, not findings of ours. Compounded medications are not FDA-approved, and a consultation does not guarantee a prescription.
Some telehealth links below are affiliate links. If you buy through them, we may earn a commission at no extra cost to you. Commission never affects which products or clinics we list, how they are ordered, or what we say about them — see our editorial policy.
Says a board-certified physician reviews each intake and prescribes through a licensed 503A compounding pharmacy where appropriate, and lists a LegitScript certification. Compounded medications are not FDA-approved.
We are not a clinic and do not prescribe. Listing a service here is not a clinical endorsement of it, and you should confirm licensure and pharmacy sourcing yourself before treatment.
Want the full Sermorelin guide?
Mechanism, clinical evidence, side effects, costs, and provider listings for Sermorelin therapy.
Medical Disclaimer: This content is for informational purposes only and should not be considered medical advice. Always consult with a qualified healthcare provider before beginning any peptide therapy treatment.