Peptide Comparison Tool
Compare any 2-3 peptide therapies side-by-side. View mechanisms of action, benefits, costs, side effects, FDA status, and evidence strength to make informed decisions.
| Attribute | Semaglutide | Tirzepatide |
|---|---|---|
| Category | Weight Loss | Weight Loss |
| Mechanism of Action | GLP-1 receptor agonist; slows gastric emptying, reduces appetite via hypothalamic signaling, improves insulin sensitivity | Dual GIP/GLP-1 receptor agonist; enhances insulin secretion, reduces glucagon, slows gastric emptying, suppresses appetite |
| Primary Benefits | Significant weight loss (15-17% body weight), improved glycemic control, cardiovascular risk reduction | Superior weight loss (20-25% body weight), excellent glycemic control, potential cardiovascular benefits |
| Typical Results Timeline | Noticeable appetite reduction in 1-2 weeks; significant weight loss by 3-6 months | Appetite suppression within 1-2 weeks; major weight loss results by 3-6 months |
| Common Side Effects | Nausea, vomiting, diarrhea, constipation, abdominal pain, injection site reactions | Nausea, diarrhea, vomiting, constipation, decreased appetite, abdominal pain |
| Typical Monthly Cost | $300-$1,600 | $400-$1,200 |
| Administration | Weekly subcutaneous injection; oral form available (Rybelsus) | Weekly subcutaneous injection |
| FDA Status | FDA-Approved | FDA-Approved |
| Evidence Strength | Strong | Strong |
Medical Disclaimer
This tool is for informational and educational purposes only and does not constitute medical advice, diagnosis, or treatment recommendations. Results are estimates based on published clinical trial data and population averages — individual results may vary significantly.
Always consult a qualified healthcare provider before starting, stopping, or modifying any peptide therapy or medication. Do not make medical decisions based solely on this tool.
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