What is the tirzepatide dosage chart in mL?

Standard Tirzepatide Titration Schedule

Both brand (Zepbound/Mounjaro) and compounded tirzepatide use the same dose-escalation schedule approved by Lilly's Phase 3 trials:

• Weeks 1–4: 2.5 mg once weekly (starting/initiation dose — not typically therapeutic)
• Weeks 5–8: 5 mg once weekly
• Weeks 9–12: 7.5 mg once weekly
• Weeks 13–16: 10 mg once weekly (therapeutic for many patients)
• Weeks 17–20: 12.5 mg once weekly
• Week 21 onward: 15 mg once weekly (maximum)

Many patients hold at 10 mg or 12.5 mg rather than escalating to 15 mg — the additional benefit at 15 mg vs 12.5 mg is incremental and side effects can be more pronounced. Dose escalation should be tolerance-based, not schedule-forced.

mg to mL Conversion for Common Compounded Concentrations

Compounded tirzepatide is typically supplied in one of several concentrations. The most common in April 2026:

40 mg/mL Vial (Most Common)

• 2.5 mg = 0.0625 mL (approx 6 units on a 100-unit insulin syringe)
• 5 mg = 0.125 mL (12.5 units)
• 7.5 mg = 0.1875 mL (19 units)
• 10 mg = 0.25 mL (25 units)
• 12.5 mg = 0.3125 mL (31 units)
• 15 mg = 0.375 mL (37.5 units)

20 mg/mL Vial

• 2.5 mg = 0.125 mL (12.5 units)
• 5 mg = 0.25 mL (25 units)
• 7.5 mg = 0.375 mL (37.5 units)
• 10 mg = 0.5 mL (50 units)
• 12.5 mg = 0.625 mL (62.5 units)
• 15 mg = 0.75 mL (75 units)

Verify Your Specific Concentration

Different pharmacies use different concentrations. Always verify the exact concentration on your vial label and follow your prescribing provider's written dose in mL — do not rely on a chart alone. A 10 mg dose in mL depends entirely on your vial's mg/mL.

Reading an Insulin Syringe

Compounded tirzepatide is typically drawn into a 100-unit (1 mL) insulin syringe. 100 units = 1 mL. To convert any dose in mL:

• Multiply mL × 100 to get "units" on the syringe
• Example: 0.125 mL = 12.5 units

Brand Pen Dosing (For Reference)

Brand Zepbound and Mounjaro pre-filled pens are pre-dosed — the pen delivers a specific amount and you don't measure mL. Pen strengths: 2.5 mg, 5 mg, 7.5 mg, 10 mg, 12.5 mg, 15 mg each per 0.5 mL single-dose pen.

When to Hold Dose Escalation

• Ongoing nausea or vomiting at current dose
• Adequate weight loss at current dose — no need to escalate
• Sulfur burps, reflux, or significant constipation that hasn't stabilized
• Any signal of pancreatitis symptoms — evaluate before escalating
• During major life stressors or changes in other medications

When to Step Down

• Intolerable GI side effects that don't resolve with supportive measures
• Undesired rapid weight loss (>1.5% per week)
• Hypoglycemia when combined with insulin or sulfonylurea
• Dehydration from persistent nausea or vomiting

Administration Notes

• Subcutaneous injection in abdomen, thigh, or upper arm
• Rotate sites weekly
• Same day of the week is standard
• Can be injected any time of day; consistency matters more than timing
• Missed dose: if less than 4 days late, take it and continue normal schedule; if more than 4 days late, skip and resume next week

See the tirzepatide guide. Related: tirzepatide cost without insurance, side effects week by week.