What is the TB-500 and BPC-157 stack dosage?

A typical TB-500 + BPC-157 stack uses BPC-157 at 500 mcg subcutaneously once or twice daily plus TB-500 at 5 mg subcutaneously twice weekly for 4–6 weeks, followed by a maintenance phase of BPC-157 250 mcg daily and TB-500 2.5 mg weekly for 4 more weeks. The stack targets complementary healing mechanisms and is often used for significant tendon, muscle, or post-surgical recovery.

TB-500 + BPC-157 Stack: Protocol, Dosing, and Timing Guide

Why Stack These Two

BPC-157 and TB-500 target different parts of the healing cascade:

BPC-157: fibroblast migration, collagen deposition, fast-acting local effects, strong on gut and tendon tissue
TB-500: angiogenesis, actin upregulation, systemic cell migration, broader tissue support

The stack addresses both the "get cells to the injury" job (TB-500) and the "rebuild the tissue matrix" job (BPC-157). For significant injuries or recovery contexts, the combined effect appears additive in clinical experience.

Standard Stack Protocol

Loading phase (weeks 1–6)

BPC-157: 500 mcg subq daily (or 250 mcg twice daily)
TB-500: 5 mg subq twice weekly (e.g., Monday and Thursday)

Maintenance phase (weeks 7–10)

BPC-157: 250 mcg subq daily
TB-500: 2.5 mg subq once weekly

Total cycle: 8–10 weeks

Injection Timing and Sites

BPC-157 injection sites

Injury-local if possible: if injury is accessible (e.g., elbow, knee), subq injection 1–2 cm from injury
Abdomen: standard subq site for systemic effect
Rotate sites to avoid tissue irritation

TB-500 injection sites

Subq injection site doesn't matter much — TB-500 is systemic
Abdomen and thigh are standard
Some practitioners do IM injection for TB-500; not required

Timing within day

Morning or evening is fine
If splitting BPC-157 to twice daily, AM/PM works well
Doesn't need to coincide with meals

When to Use This Stack

Good candidates

Acute significant muscle strain or partial tear
Chronic tendonitis (rotator cuff, Achilles, patellar)
Post-surgical recovery (arthroscopic, soft tissue repair)
Severe overuse injuries not responding to rest + PT
Chronic joint pain with soft-tissue involvement
Pre-planned injury risk (e.g., athletes heading into high-stress training blocks)

Not appropriate for

Complete tendon rupture (needs surgery first)
Acute fracture without surgical stabilization
Active cancer patients or those with family history of angiogenesis-driven conditions
Pregnancy or active conception
Uncontrolled medical conditions without prescriber supervision

Expected Timeline and Outcomes

Week 1–2: BPC-157 effects may start showing (pain reduction, better sleep); TB-500 still building
Week 3–4: noticeable functional improvement for most responders
Week 5–6: substantial progress; begin transitioning to maintenance
Week 7–10: continued improvement; preservation of gains
Post-cycle: gains typically persist; may cycle again if needed after 4–8 week break

Reconstitution and Handling

BPC-157 reconstitution

5 mg vial + 2 mL bacteriostatic water = 2.5 mg/mL
For 500 mcg dose: draw 0.2 mL (20 units on U-100 syringe)

TB-500 reconstitution

5 mg vial + 2 mL bacteriostatic water = 2.5 mg/mL
For 5 mg dose: draw 2 mL (full 100 units on U-100 syringe or split into two injections)

Storage

Reconstituted vials: refrigerated (36–46°F)
Use within 4 weeks of reconstitution
Avoid freezing; avoid vigorous shaking

Monthly Cost

BPC-157: $100–$250/month at 500 mcg daily
TB-500: $300–$600/month at 5 mg twice weekly
Combined stack: $400–$850/month

Combining With Other Therapies

Physical therapy

Essential. Peptides accelerate tissue healing; loaded rehabilitation drives tissue remodeling. Don't use the stack as a reason to skip PT.

NSAIDs

Low-dose occasional NSAIDs for pain management are fine. Long-term high-dose NSAIDs may blunt the tissue repair signal and partially work against peptide mechanisms.

Collagen supplementation

15–20 g hydrolyzed collagen daily appears to modestly enhance tendon and ligament repair; complementary to peptides.

Vitamin C

500–1000 mg daily supports collagen synthesis; useful adjunct.

Sleep and nutrition

7+ hours of sleep, adequate protein (1.2+ g/kg/day), and stable blood sugar all dramatically improve healing outcomes. Peptides can't overcome poor fundamentals.

Red Flags During Cycle

Stop and consult a provider if:

Unexplained significant weight change
New persistent pain outside injury area
Signs of infection at injection sites
Lymph node swelling
New symptoms suggesting undiagnosed condition

Cycling Between Stacks

Typical pattern for someone with recurrent issues:

8–10 week stack cycle
4–8 week off period
Repeat if needed

Avoid continuous indefinite dosing; cyclic use is the clinical norm.

Bottom Line

BPC-157 500 mcg daily + TB-500 5 mg twice weekly for 6 weeks is the canonical stack. Pair with physical therapy, adequate protein, and sleep. Expect measurable improvement by week 4 in responders. Total cost $400–$850/month. Not a substitute for appropriate medical care for significant injuries.

See the TB-500 guide and BPC-157 guide.