What is the BPC-157 and TB-500 Wolverine Stack dosage?

The Wolverine Stack combines BPC-157 (typically 250–500 mcg/day) with TB-500 (typically 2 mg twice weekly during a 4-week loading phase, then 2 mg weekly for maintenance). The peptides are injected separately, not mixed. Expected use is 6–8 weeks during an acute injury-recovery phase.

BPC-157 + TB-500 (Wolverine Stack) Dosage Guide 2026

What the "Wolverine Stack" Is

The Wolverine Stack is the colloquial name for a combination protocol using BPC-157 and TB-500 (Thymosin Beta-4 fragment) together for accelerated soft-tissue recovery. It originated in bodybuilding and combat-sports communities and migrated into sports medicine practice over the last five years. The logic is complementary mechanisms: BPC-157 promotes angiogenesis and local fibroblast activity; TB-500 promotes cell migration and broader systemic repair signaling.

Typical Loading-Phase Dosing

Most Wolverine Stack protocols have a distinct loading phase (weeks 1–4) followed by a maintenance phase (weeks 5–8+). Representative loading dosing:

BPC-157: 250 mcg twice daily subcutaneously (500 mcg/day total), site-rotated
TB-500: 2 mg twice weekly subcutaneously (4 mg/week total)

Typical Maintenance-Phase Dosing

BPC-157: 250 mcg once daily subcutaneously
TB-500: 2 mg once weekly subcutaneously

Do Not Mix Them in the Same Syringe

A frequently asked question: can you draw BPC-157 and TB-500 into the same syringe and inject once? The practical answer is no. The two peptides have different reconstitution requirements, storage stabilities, and potential for chemical interaction. Mixing them in a single vial or syringe risks degradation of one or both. Inject them separately, even if administered back-to-back during the same session.

Injection Timing

Practical scheduling used by experienced practitioners:

Morning: BPC-157 (morning dose), rotating between abdomen and site near injury
Evening: BPC-157 (evening dose)
Twice a week (e.g., Monday and Thursday) during loading: add the TB-500 dose — can be given with either the morning or evening BPC-157 dose, separate injection site and separate syringe

How Long to Run the Stack

Most practitioners run the Wolverine Stack for 6–8 weeks per cycle, with a 2–4 week washout before considering another cycle. Continuous use beyond 12 weeks is not well studied in humans and is generally discouraged without ongoing medical oversight.

When the Stack Makes Sense

Acute soft-tissue injury (tendon, ligament, muscle) where accelerated recovery is the goal
Post-surgical rehabilitation (with surgical team approval, typically starting 2+ weeks post-op)
Chronic tendinopathy that has been unresponsive to physical therapy alone
Athletic recovery from high-intensity training blocks

When to Skip the Stack and Use BPC-157 Alone

TB-500 is more expensive, less widely available, and has a weaker human evidence base than BPC-157. For many routine applications — mild tendinopathy, gut-focused protocols, general recovery — BPC-157 monotherapy is sufficient and the added complexity and cost of TB-500 is not justified. Reserve the Wolverine Stack for significant injuries where maximum healing signal is desired.

Safety Notes

Both peptides are research peptides without FDA approval. Access is through 503A/503B compounding pharmacies under practitioner supervision.
Both peptides have pro-angiogenic effects — meaning they promote new blood vessel growth. Patients with active or suspected malignancy should avoid the stack until cleared, since tumor growth also depends on angiogenesis.
Injection-site reactions are the most common side effect. Rotate sites daily.
If any unusual systemic symptoms emerge (unexplained fatigue, mood changes, blood pressure changes), pause the stack and consult your provider.

See our BPC-157 guide and TB-500 guide for full clinical context. Related: BPC-157 dosing for tendonitis, BPC-157 legal status 2026.