How many mcg of BPC-157 should I take per day?

The Standard Range

Across peptide-therapy clinical practice and the limited published dose-ranging data, the typical effective daily dose of BPC-157 is 250–500 mcg. This is the range that most experienced practitioners converge on, and the range where clinical response is most consistently reported.

Choosing a Starting Dose

250 mcg per day — Lower Range

Good starting point for:

• Gut-focused protocols (IBS, leaky gut, mild GI inflammation)
• First-time users who want to assess tolerability
• Smaller-framed patients (though strict weight-based dosing is not well established)
• Chronic low-grade issues without acute injury
• Cost-sensitive protocols

500 mcg per day — Standard Therapeutic Range

Appropriate for:

• Tendinopathy (tendonitis, epicondylitis, plantar fasciitis)
• Rotator cuff partial tears
• Muscle strains and localized injuries
• Post-surgical recovery
• Users who saw partial response at 250 mcg and need more

Above 500 mcg — Not Common, Not Well-Supported

Doses of 750–1,000 mcg/day are sometimes used for severe or unresponsive cases under direct medical oversight. Going higher than that has weak evidence behind it and provides diminishing returns — at some point, receptor saturation or related effects likely cap the benefit.

Single Dose vs Split Dose

Once Daily

• Simpler — one injection, one schedule to remember
• Appropriate at lower doses (250 mcg)
• Many practitioners prefer morning dosing

Split (Morning and Evening)

• Smoother pharmacokinetic profile
• Better tolerability for some users at higher total daily doses
• Preferred for the 500 mcg/day range
• Injection sites can be rotated more thoroughly

BPC-157's half-life in humans is not precisely characterized, but split dosing is a reasonable conservative choice for higher daily totals.

Weight-Based Dosing — Mostly a Myth

Some online protocols advocate weight-based BPC-157 dosing (e.g., 2–4 mcg/kg/day). There is no strong clinical evidence that strict weight-based dosing produces better outcomes than the standard 250–500 mcg/day range across normal adult body weights. For patients at extreme ends of body weight (very low or very high), discussion with your provider is sensible, but most protocols stay in the standard range regardless.

How to Dial In Your Dose

Practical approach:

• Start at 250 mcg/day for 2 weeks
• Assess response — pain, function, symptom markers
• If meaningful improvement, stay at 250 mcg/day and continue cycle
• If partial or no improvement at week 2, increase to 500 mcg/day (split morning/evening)
• Reassess at week 4 and week 8
• If still no response at week 4 on 500 mcg/day, rethink the protocol (see why BPC-157 isn't working) rather than defaulting to higher doses

When to Reduce Your Dose

• Significant injection-site reactions or local irritation
• Persistent mild nausea or headache
• Any new systemic symptom that resolves with dose reduction
• After a maintenance phase has been reached and the acute issue has resolved

See the main BPC-157 guide. Related: dosing for tendonitis, cycle length.